Metandienone Wikipedia
Metandienone
Metandienone (also known as Dianabol) is a synthetic anabolic‑steroid derivative of testosterone. It was first synthesized in the 1950s and became popular among athletes and bodybuilders for its ability to increase muscle mass, strength, and overall physical performance. Chemically, it differs from natural testosterone by having a methylenedioxy group at the 2‑position of the A‑ring and a methyl group on the 17α position, which gives it oral bioavailability and reduces the risk of aromatization to estrogen.
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Pharmacology
| Property | Effect |
|---|---|
| Oral activity | The 17α‑methyl group protects the compound from hepatic metabolism, allowing it to be taken orally. |
| Anabolic potency | High; stimulates protein synthesis and reduces protein breakdown. |
| Aromatization | Minimal; no significant conversion to estrogenic metabolites. |
| Androgenic effects | Present but lower than anabolic actions; can cause androgen‑related side effects in susceptible individuals. |
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Therapeutic Uses
- Muscle wasting disorders – e.g., chronic renal failure, HIV‑associated cachexia.
- Chronic inflammatory conditions – improves strength and endurance in patients with prolonged illness.
- Rehabilitation after surgery or trauma where muscle mass is at risk.
Dosage & Administration
| Regimen | Typical Dose (mg/day) |
|---|---|
| Phase 1 – Loading | 20–25 mg/day (in divided doses) for 4–6 weeks |
| Phase 2 – Maintenance | 5–10 mg/day thereafter, as needed |
- Timing: Preferably taken with meals to reduce GI upset.
- Cycle Length: Commonly a single cycle per year; no cumulative toxicity noted.
Monitoring & Follow‑up
| Parameter | Frequency | Goal |
|---|---|---|
| CBC + CMP | Baseline, then monthly | Detect early hematologic or hepatic changes |
| Weight, BP | Baseline, then every 4 weeks | Monitor for fluid retention |
| GI symptoms | At each visit | Manage nausea/diarrhea promptly |
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Potential Complications
- Fluid Retention / Edema: Mild; treat with diuretics if symptomatic.
- Hepatic Enzyme Elevation: Rare; discontinue if ALT/AST > 3× ULN.
- Allergic Reactions: Anaphylaxis uncommon but possible; monitor for rash or itching.
Patient Education
- Medication Administration
- Avoid mixing with other anticoagulants unless instructed by a healthcare provider.
- Monitoring Symptoms
- Seek immediate medical attention for signs of severe allergic reaction (rash spreading rapidly, itching, swelling).
- Lifestyle & Safety
- Maintain a balanced diet; avoid excessive vitamin K intake unless advised by your physician.
- Follow-Up Care
- Keep an updated medication list and inform new healthcare providers about this prescription.
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Contact Information
- Medical Center:
Email: patientcare@medicalcenter.org
- Pharmacy:
Address: 1000 Health Blvd, Suite 200, Cityville
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Prepared by: _________________________
(Date) __________
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